کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5734132 1612515 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GastrointestinalImpact of body mass index on the short-term outcomes of resected gastrointestinal stromal tumors
ترجمه فارسی عنوان
معاینه دستگاه گوارشی بر شاخص توده بدنی بر نتایج کوتاه مدت تومورهای استرومای مجدد دستگاه گوارش
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

BackgroundPotentially curative treatment for gastrointestinal stromal tumors (GIST) involves resection with selective utilization of tyrosine kinase inhibitors. A potential association between obesity and GIST has been postulated as GIST is among the most common incidental findings during gastric resection for bariatric procedures. The purpose of this study is to investigate the relationship and impact of obesity on the pathologic and short-term outcomes in patients with GIST.MethodsWe performed a retrospective review of patients with resected GIST. The impact of obesity, defined as body mass index (BMI) ≥30 kg/m2, on pathologic results and short-term outcomes was evaluated.ResultsSixty-one patients underwent resection with a median follow-up of 26 mo (1-129 mo). Disease involved the stomach (74%), small intestine (18%), or colon/rectum (5%). Median tumor size was 6 cm, and 13 patients (21%) underwent multivisceral resection. Median BMI for the cohort was 27.2 kg/m2, and 24 patients (39%) were classified as obese based on BMI. Nonobese patients were noted to have larger primary tumors (median: 7 cm versus 5 cm, P = 0.02) and undergo multivisceral resection more frequently (32.4% versus 4.2%, P < 0.01). Short-term outcomes were similar between the groups, with a slight trend toward more postoperative complications among the obese patients.ConclusionsIn this study, obese patients tended to have more favorable pathologic features. GISTs may represent another example of the “obesity paradox” in which obesity seemingly provides a protective effect. Larger studies are warranted to verify the impact of obesity on outcomes and to elucidate any underlying clinicopathologic/biologic factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 217, September 2017, Pages 123-130
نویسندگان
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