کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736260 | 1613226 | 2017 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered functional efficacy of hippocampal interneuron during epileptogenesis following febrile seizures
ترجمه فارسی عنوان
اثربخشی عملکردی اینترنئورون هیپوکامپ در طی اپیلوتوژنز پس از تشنج ناشی از تب
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کلمات کلیدی
TLEpaired-pulse responseSTPsfEPSPLFPPBSγ-aminobutyric acid - اسید γ-آمینوبوتیریکPopulation spike - افزایش جمعیتepileptogenesis - اپیلوتوژنز، صرع زاییstatus epilepticus - بحران صرعی یا صرع پایدارfebrile seizure - تشنج ناشی از تبlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP dentate gyrus - شکنج دندانه دارtemporal lobe epilepsy - صرع لوب تمپورالPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریlocal field potentials - پتانسیل های زمینه محلیField excitatory postsynaptic potential - پتانسیل پستنیپتیک مزمن تحریک پذیرCalretinin - کالورتینینGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Febrile seizure (FS) is the most common seizure type in infants and young children. FS may induce functional changes in the hippocampal circuitries. Abnormality of excitatory and inhibitory neurotransmissions was previously related to wide-spread seizure attack in the hippocampus following recurrent seizure onset. To clarify the involvement of expressional changes and functional alterations of hippocampal interneurons with epileptogenesis following FS, we investigated long-term effects following recurrent seizure in a hyperthermia-induced seizure animal model. At 12 weeks following FS, the recurrent seizure time period, local field potentials (LFP) revealed high amplitude potential and a sharp wave characteristic of epilepsy. Mossy fiber reorganization in the hippocampus was also detected as abnormal synaptic connection at 8 weeks. Calretinin (CR) âpositive interneurons were transiently enhanced during epileptogenic period at 7-9 weeks after FS in the CA1 and DG region and it is double labeled with VGLUT-1. However, although GABAA-α1 immunoreactivities were un-changed as similar to control hippocampus at 7-9 weeks after seizure onset, its expression was significantly enhanced at 4 weeks and 12 weeks and it is colocalized with GABA. Furthermore, the field excitatory postsynaptic potential (fEPSP) and the paired-pulse responses including population spike (PS) latency, excitability ratio and PS2/PS1 ratio were markedly altered in the CA1 and DG region at 12 weeks after FS. Therefore, our findings in present study indicate that these time-dependent changes may be based on the persistent alterations of hippocampal neuronal circuits in balance between excitatory and inhibitory responses, and may lead to the epileptogenesis and spread of seizure activity following FS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 131, May 2017, Pages 25-38
Journal: Brain Research Bulletin - Volume 131, May 2017, Pages 25-38
نویسندگان
Yeon Hee Yu, Kahyun Lee, Dal Sik Sin, Kyung-Ho Park, Dae-Kyoon Park, Duk-Soo Kim,