کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736312 | 1613223 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of CXCR2 inhibition on seizure activity in the pilocarpine epilepsy mouse model
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کلمات کلیدی
STAT3PFHSRSsCXCR2IL6CXCL1MAP2AEDsTLEIL8FITCGFAPDMSO - DMSOERK1/2 - ERK1 / 2Electroencephalogram - الکتروانسفالوگرافیInterleukin-8 - اینترلوکین -8interleukin-6 - اینترلوکین ۶Epilepsy - بیماری صرعSeizures - تشنجspontaneous recurrent seizures - تشنج مجدد خودبخودیantiepileptic drugs - داروهای ضدصرع CNS - دستگاه عصبی مرکزیDimethylsulfoxide - دیمتیل سولفواکسیدcentral nervous system - سیستم عصبی مرکزیtemporal lobe epilepsy - صرع لوب تمپورالfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3EEG - نوار مغزیparaformaldehyde - پارافرمالدهیدGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالmicrotubule-associated protein 2 - پروتئین مرتبط با میکروتوبول 2Pilocarpine - پیلوکارپینextracellular signal-regulated kinase 1/2 - کیناز 1/2 تنظیم سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The effect of CXCR2 inhibition on seizure activity in the pilocarpine epilepsy mouse model The effect of CXCR2 inhibition on seizure activity in the pilocarpine epilepsy mouse model](/preview/png/5736312.png)
چکیده انگلیسی
C-X-C motif chemokine receptor 2 (CXCR2) is one of the most well characterized chemokine receptors and is a potential target for treating brain pathologies involving inflammatory processes, including epilepsy. However, the role of CXCR2 in epilepsy has not been investigated, and whether CXCR2 modulates seizure activity in temporal lobe epilepsy (TLE) remains unknown. In this study, we aimed to determine the potential role of CXCR2 in intractable TLE patients and in pilocarpine-induced epileptic mice. Here, through Western blotting and semi-quantitative immunohistochemistry, we detected that CXCR2 protein expression was up-regulated (by nearly 50%) in the temporal neocortex of TLE patients and in the hippocampus and adjacent temporal cortex of pilocarpine mice model. Double-label immunofluorescence and immunohistochemical analysis indicated that CXCR2 was expressed in neurons. To investigate the effect of the CXCR2 selective antagonist SB225002 on seizure activity, SB225002 was i.p. administered during the latency window of spontaneous recurrent seizures (SRSs). This treatment increased (by nearly 40%) the latency of SRSs and reduced (by nearly 50%) the frequency of SRSs during the chronic period of epilepsy. This study suggests that CXCR2 plays a critical role in modifying epileptic seizure activity and that CXCR2 blockade could be a potential molecular therapeutic target for epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 134, September 2017, Pages 91-98
Journal: Brain Research Bulletin - Volume 134, September 2017, Pages 91-98
نویسندگان
Tao Xu, Xinyuan Yu, Teng Wang, Ying Liu, Xi Liu, Shu Ou, Yangmei Chen,