کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5736503 1613777 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportLow frequency electrical stimulation has time dependent improving effect on kindling-induced impairment in long-term potentiation in rats
ترجمه فارسی عنوان
تحقیقات تحقیقاتی تحلیل الکترومغناطیسی با کمک زمان تأثیر گذار بر تأثیر ناشی از کیندلینگ در کاهش طولانی مدت در موش صحرایی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Long-term potentiation (LTP) cannot be induced in hippocampus up to 1 month after kindling.
- Low-frequency stimulation (LFS) alleviated kindling-induced deficit in LTP induction.
- Improving effect of LFS on LTP induction remained up to one week in kindled animals.
- LFS effects extended up to one month by increasing the number of its applications.

Application of low-frequency stimulation (LFS) can improve learning and memory in kindled animals (Ghafouri et al., 2016). Considering the important role of long-term potentiation (LTP) in learning and memory, in the present study the effectiveness of LFS on kindling-induced impairment in LTP induction was investigated in hippocampal CA1 area at different times post kindling stimulations. Animals were kindled via electrical stimulation of hippocampal CA1 area in a semi-rapid manner (12 stimulations per day). One group of animals received four trials of LFS at 30 s, 6 h, 24 h, and 30 h following the last kindling stimulation. Each LFS consisted of 4 packages at 5 min intervals; each package contained 200 monophasic square wave pulses of 0.1 ms duration at 1 Hz. The kindled, kindled + LFS and LFS groups were divided into four subgroups in which hippocampal slices were prepared at 48 h, 1 week, 2 weeks, and 1 month following the last kindling stimulation respectively. Extracellular evoked field excitatory postsynaptic potentials (fEPSPs) were recorded in the stratum radiatum of the CA1 area of the slice. Obtained results showed that LTP was not induced in kindled animals. However, application of LFS overcame the kindling-induced impairment in LTP generation in CA1 area of the hippocampus. This improving effect remained up to one week after the last kindling stimulation and extended to one month by increasing the number of applied LFS packages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1668, 1 August 2017, Pages 20-27
نویسندگان
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