کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736592 | 1613768 | 2017 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activity-based anorexia activates nesfatin-1 immunoreactive neurons in distinct brain nuclei of female rats
ترجمه فارسی عنوان
بی اشتهایی مبتنی بر فعالیت، نورون های ایمونوآرایی ناسفاتین-1 را در هسته های مجزا مغز موش های ماده فعال می کند
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کلمات کلیدی
ICVα-MSHRostral raphe pallidusNUCB2intracerebroventricularCRFDMHBrain-gutACTHABArRPAEating disorder - اختلال خوردنAnorexia nervosa - بیاشتهایی عصبیintraperitoneal - داخل صفاقیPsychosomatic - روانشناسیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینSON - فرزند پسرArc - قوسlocus coeruleus - لوکوس سیرولئوسPVN - مالیات بر ارزش افزودهHypothalamus-pituitary-adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالHPA axis - محور هیپوتالاموس-هیپوفیز-آدرنالAnimal model - مدل حیوانیEdinger-Westphal nucleus - هستن Edinger-WestphalSupraoptic nucleus - هسته Supraopticdorsal raphe nucleus - هسته رافهarcuate nucleus - هسته قوسdorsomedial hypothalamic nucleus - هسته هیپوتالاموس dorsomedialparaventricular nucleus - هسته پروژسترویکadrenocorticotropic hormone - هورمون adrenocorticotropicalpha-melanocyte stimulating hormone - هورمون تحریک کننده آلفا ملانوستی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Activity-based anorexia (ABA) is an established animal model for the eating disorder anorexia nervosa (AN). The pathophysiology of AN and the involvement of food intake-regulatory peptides is still poorly understood. Nesfatin-1, an anorexigenic peptide also involved in the mediation of stress, anxiety and depression might be a likely candidate involved in the pathogenesis of AN. Therefore, activation of nesfatin-1 immunoreactive (ir) brain nuclei was investigated under conditions of ABA. Female Sprague-Dawley rats were used and divided into four groups (n = 6/group): activity-based anorexia (ABA), restricted feeding (RF), activity (AC) and ad libitum fed (AL). After the 21-day experimental period and development of ABA, brains were processed for c-Fos/nesfatin-1 double labeling immunohistochemistry. ABA increased the number of nesfatin-1 immunopositive neurons in the paraventricular nucleus, arcuate nucleus, dorsomedial hypothalamic nucleus, locus coeruleus and in the rostral part of the nucleus of the solitary tract compared to AL and AC groups (p < 0.05) but not to RF rats (p > 0.05). Moreover, we observed significantly more c-Fos and nesfatin-1 ir double-labeled cells in ABA rats compared to RF, AL and AC in the supraoptic nucleus (p < 0.05) and compared to AL and AC in the paraventricular nucleus, arcuate nucleus, dorsomedial hypothalamic nucleus, dorsal raphe nucleus and the rostral raphe pallidus (p < 0.05). Since nesfatin-1 plays a role in the inhibition of food intake and the response to stress, we hypothesize that the observed changes of brain nesfatin-1 might play a role in the pathophysiology and symptomatology under conditions of ABA and potentially also in patients with AN.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1677, 15 December 2017, Pages 33-46
Journal: Brain Research - Volume 1677, 15 December 2017, Pages 33-46
نویسندگان
Sophie Scharner, Philip Prinz, Miriam Goebel-Stengel, Reinhard Lommel, Peter Kobelt, Tobias Hofmann, Matthias Rose, Andreas Stengel,