کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736684 | 1613775 | 2017 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cold stress-induced brain injury regulates TRPV1 channels and the PI3K/AKT signaling pathway
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cold stress-induced brain injury regulates TRPV1 channels and the PI3K/AKT signaling pathway Cold stress-induced brain injury regulates TRPV1 channels and the PI3K/AKT signaling pathway](/preview/png/5736684.png)
چکیده انگلیسی
Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that interacts with several intracellular proteins in vivo, including calmodulin and Phosphatidylinositol-3-Kinase/Protein Kinase B (PI3K/Akt). TRPV1 activation has been reported to exert neuroprotective effects. The aim of this study was to examine the impact of cold stress on the mouse brain and the underlying mechanisms of TRPV1 involvement. Adult male C57BL/6 mice were subjected to cold stress (4 °C for 8 h per day for 2 weeks). The behavioral deficits of the mice were then measured using the Morris water maze. Expression levels of brain injury-related proteins and mRNA were measured by western blot, immunofluorescence or RT-PCR analysis. The mice displayed behavioral deficits, inflammation and changes in brain injury markers following cold stress. As expected, upregulated TRPV1 expression levels and changes in PI3K/Akt expression were found. The TRPV1 inhibitor reduced the levels of brain injury-related proteins and inflammation. These data suggest that cold stress can induce brain injury, possibly through TRPV1 activation and the PI3K/Akt signaling pathway. Suppression of inflammation by inhibition of TRPV1 and the PI3K/Akt pathway may be helpful to prevent cold stress-induced brain injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1670, 1 September 2017, Pages 201-207
Journal: Brain Research - Volume 1670, 1 September 2017, Pages 201-207
نویسندگان
Ying Liu, Yunen Liu, Hongxu Jin, Peifang Cong, Yubiao Zhang, Changci Tong, Xiuyun Shi, Xuelei Liu, Zhou Tong, Lin Shi, Mingxiao Hou,