کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737772 | 1614732 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Group comparison of cortical fiber connectivity map: An application between post-stroke patients and healthy subjects
ترجمه فارسی عنوان
مقایسه گروهی از نقشه ارتباط کلیه فیبر: برنامه کاربردی بین بیماران پس از سکته مغزی و افراد سالم
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کلمات کلیدی
AFSAssociation fibersT1WIVLSMIITFCDConnectomeMNIMMSEVBMTBSSThree-dimensionalGLMFWHMFFEdMRI - DMRItract-based spatial statistics - آمار مکانی مبتنی بر تراکمstructural connectivity - ارتباط ساختاریFLAIR - اشتباهFast field echo - اچ خروجی سریعfluid attenuation inversion recovery - بازیابی معکوس کاهش مایعfunctional connectivity density - تراکم ارتباطی عملکردیT1-weighted image - تصویر T1 وزنDiffusion magnetic resonance imaging - تصویربرداری رزونانس مغناطیسیTIR - تیرNINDS - شبهاfull width at half maximum - عرض کامل در نیمی از حداکثرCortex - قشرwhite matter - ماده سفیدGLM, General Linear Model - مدل خطی عمومیMontreal Neurological Institute - موسسه عصبی مونترالfractional anisotropy - ناپیوستگی کسری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Structural connectome measurement combined with diffusion magnetic resonance imaging (MRI) and tractography allows generation of a whole-brain connectome. However, current cortical structural connectivity (SC) measurements have not been well combined with the vertex-wise multi-subjects statistical analysis. The aim of this study was to examine the feasibility of using group comparison vertex-wise analysis for cortical SC measurement. A fiber connectivity density (FiCD) method based on a combination of a diffusion fiber tracking technique and cortical surface-based analysis was used to measure the whole-brain cortical SC map (FiCD map). A public MRI dataset (GigaDB) was employed to evaluate the reproducibility of the FiCD method. For group comparison, 14 post-stroke patients (mean age, 68.36 ± 7.33 y) and 19 healthy participants (mean age, 66.84 ± 8.58 y) had FiCD measurement. The intergroup comparison of the FiCD map was performed using vertex-wise multi-subject statistical analysis. Reliability testing showed the mean intra- and inter-subject FiCD variability was 3.51 ± 2.12% and 19.44 ± 4.79%, respectively. The group comparison of the whole-brain FiCD identified cortical regions with altered FiCD values, and there was a spatial consistency between the cortical clusters with low FiCD values and the subcortical lesions of patients. This study demonstrated the feasibility of vertex-wise group comparison for evaluating cortical fiber connectivity density. The FiCD method has good intra- and inter-individual reproducibility, and accurately reflects the affected cortical regions in post-stroke patients. This method may be helpful for neuroscience research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 15-24
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 15-24
نویسندگان
Kai Liu, Teng Zhang, Winnie C.W. Chu, Vincent C.T. Mok, Defeng Wang, Lin Shi,