کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737879 | 1614733 | 2017 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations of acute and chronic stress hormones with cognitive functions in autism spectrum disorder
ترجمه فارسی عنوان
انجمن های هورمون استرس حاد و مزمن با توابع شناختی در اختلال طیف اوتیسم
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کلمات کلیدی
ROCAutism-spectrum QuotientFIQWCSTNeurodevelopmental disorder - اختلال نوروپاتولوژیAutism spectrum disorder - اختلالات طیف اوتیسم گروهیAnxiety - اضطرابtypically developing - به طور معمول در حال توسعه استBiomarker - بیومارکرEnzyme-linked immunosorbent assay - تست الیزاELISA - تست الیزاWisconsin Card Sorting Test - تست مرتب سازی کارت ویسکانسینWorking memory - حافظه فعال یا حافظه کاریfull-scale intelligence quotient - مقیاس اطلاعات جامعRMET - نزدیکASD - نقص سپتوم یا دیوارهی دهلیزیcortisol - کورتیزولreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Extensive studies have reported cognitive abnormalities in neurodevelopmental disorders, such as autism spectrum disorder (ASD). Another line of evidence suggests that stress also affects cognitive functions. In this study, we investigated whether there were associations between stress hormones and cognitive functions in ASD and typically developing (TD) children. Cognitive functions in ASD and TD children were evaluated with a battery of psychological tests for working memory, behavioral flexibility, and social cognition for emotional assessments of others. ASD children exhibited higher hair and salivary cortisol, which reflects chronic and acute stress hormone levels of subjects, respectively, than TD children. Autism-spectrum quotient (AQ) was positively correlated with hair cortisol and the scores of Spence Children's Anxiety Scale in ASD children. In addition, a negative correlation was present between spatial working memory performance and hair cortisol in ASD, but not in TD, children. These results suggest that chronic stress hormone elevation may have relationships with some aspects of cognitive dysfunction in ASD subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 343, 20 February 2017, Pages 229-239
Journal: Neuroscience - Volume 343, 20 February 2017, Pages 229-239
نویسندگان
Shino Ogawa, Young-A Lee, Yoshie Yamaguchi, Yuka Shibata, Yukiori Goto,