کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738005 | 1614731 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Opposing effects of acute and chronic d-amphetamine on decision-making in rats
ترجمه فارسی عنوان
اثرات متقابل دوزای آمفتامین حاد و مزمن بر تصمیم گیری در موش صحرایی
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کلمات کلیدی
PBSRPEMSNsAMPHDMSPFADLSdorsolateral striatum - striatum dorsolateraldorsomedial striatum - striatum dorsomedialVentral striatum - Striatum درشتAmphetamine - آمفتامین هاStriatum - استریاتومAddiction - اعتیاد Decision-making - تصمیم گیریReward prediction error - خطای پیش بینی پاداشDopamine - دوپامینPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریmedium spiny neurons - نورونهای کروی متوسطparaformaldehyde - پارافرمالدهیدLearning - یادگیری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Amphetamine and other drugs of abuse have both short-term and long-lasting effects on brain function, and drug sensitization paradigms often result in chronic impairments in behavioral flexibility. Here we show that acute amphetamine administration temporarily renders rats less sensitive to reward omission, as revealed by a decrease in lose-shift responding during a binary choice task. Intracerebral infusions of amphetamine into the ventral striatum did not affect lose-shift responding but did increase impulsive behavior in which rats chose to check both reward feeders before beginning the next trial. In contrast to acute systemic and intracerebral infusions, sensitization through repeated exposure induced long-lasting increased sensitivity to reward omission. These treatments did not affect choices on trials following reward delivery (i.e. win-stay responding), and sensitization increased spine density in the sensorimotor striatum. The dichotomous effects of amphetamine on short-term and long-term loss sensitivity, and the null effect on win-stay responding, are consistent with a shift of behavioral control to the sensorimotor striatum after drug sensitization. These data provide a new demonstration of such a shift in a novel task unrelated to drug administration, and suggests that the dominance of sensorimotor control persists over many hundreds of trials after sensitization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 345, 14 March 2017, Pages 218-228
Journal: Neuroscience - Volume 345, 14 March 2017, Pages 218-228
نویسندگان
Scott A. Wong, Raj Thapa, Cecilia A. Badenhorst, Alicia R. Briggs, Justan A. Sawada, Aaron J. Gruber,