Research articleLack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population

- We have investigated the association between polymorphisms in the solute carrier family 5, member 7 gene (SLC5A7) and Tourette syndrome (TS) in a Chinese Han population.
- We combined a family-based analysis with a case-control study which may supply an authentic interpretation for our hypothesis.
- SLC5A7 polymorphisms rs1013940, rs2433718, and rs4676169 were genotyped in 401 TS trios and 400 controls. The transmission disequilibrium test (TDT) and haplotype relative risk (HRR) compared genetic distributions of trios, while the chi-square test compared patients and controls.
- No significant association was identified between SLC5A7 and TS in a Chinese Han population, indicating this gene may not be the main risk factor.

Although Tourette syndrome (TS) is a chronic neuropsychiatric disorder whose pathogenesis remains unclear, genetic factors play an important role in the occurrence and development. A variety of studies have been shown that the candidate genes related to cholinergic neurons may be associated with the onset of TS. To investigate the association between the SLC5A7 polymorphisms and Tourette syndrome (TS) in the Chinese Han population, the SNP rs1013940, rs2433718, and rs4676169 were genotyped in 401 TS trios and 400 controls. The transmission disequilibrium test (TDT) and haplotype relative risk (HRR) compared genetic distributions of trios, while the chi-square test compared patients and controls. However, no transmission disequilibrium was found between the three SLC5A7 SNPs and TS. Therefore, we think that this gene may not be the main risk factor on the onset of TS. However, these results should be further validated in different populations.