کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738168 1615040 2017 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tanshinone IIA attenuates nerve transection injury associated with nerve regeneration promotion in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Tanshinone IIA attenuates nerve transection injury associated with nerve regeneration promotion in rats
چکیده انگلیسی
Tanshinone IIA (Tan IIA) is the major pharmacological constituent of Salvia miltiorrhiza Bunge (Danshen) for the therapeutic purpose of preventing ischemic injury and treating cerebrovascular disease. The aim of the present study was to explore the potential neuroprotective effects of Tan IIA in sciatic nerve transection injury. We investigated the possible beneficial effects of Tan IIA in promoting nerve regeneration after nerve transection injury in rats. Nerve transection injury was induced in male Sprague-Dawley rats by left sciatic nerve transection. After neuroanastomosis, the rats were intraperitoneally (IP) injected with 6 mg/kg, 15 mg/kg, or 40 mg/kg Tan IIA once daily for 12 weeks; the vehicle and positive control groups were injected with normal saline and mecobalamin (MeCbl, 100 μg/kg), respectively. Axonal regeneration and functional recovery were evaluated by a range of morphological and functional measures 12 weeks after neuroanastomosis. The administration of 15 mg/kg and 40 mg/kg Tan IIA and MeCbl achieved better axonal regeneration with significant restoration of motor function as well as a marked decrease in Fluoro-Gold (FG)-labeled neurons and increased nerve regeneration. At 12 weeks post-surgery, 40 mg/kg Tan IIA showed a better neuroprotective effect than 15 mg/kg Tan IIA and MeCbl. There were no statistical differences between the 15 mg/kg Tan IIA and MeCbl groups or the control and 6 mg/kg Tan IIA groups. Our findings demonstrate that Tan IIA can alleviate nerve injury and promote nerve regeneration in a sciatic nerve transection model in rats, providing supportive evidence for Tan IIA as an effective potential therapeutic remedy for peripheral nerve injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 659, 17 October 2017, Pages 18-25
نویسندگان
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