کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738274 1615043 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of environmental enrichment during abstinence in morphine dependent parents on anxiety, depressive-like behaviors and voluntary morphine consumption in rat offspring
ترجمه فارسی عنوان
اثرات غنی سازی محیط زیست در هنگام شکنندگی والدین وابسته به مرفین بر اضطراب، رفتارهای افسردگی و مصرف مورفین داوطلبانه در فرزندان موش صحرایی
کلمات کلیدی
محیط غنی شده موش های والدین وابسته به مورفین، اضطراب، افسردگی، مصرف مورفین داوطلبانه،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Chronic morphine exposure during puberty increased morphine-induced rewarding effects and sensitization in the next generation. Given the well-known beneficial effects of environmental enrichment on the severity of physical and psychological dependence on morphine, we examined effects of enriched environment during morphine abstinence in morphine dependent parental rats before mating on the anxiety and depressive-like behaviors, and voluntary morphine consumption in their offspring. Paternal and/or maternal rats were injected with bi-daily doses (10 mg/kg, 12 h intervals) of morphine for 14 days followed by rearing in a standard environment (SE) or enriched environment (EE) during 30 days of morphine abstinence before mating. The pubertal male and female rat offspring were tested for anxiety (the elevated plus maze- EPM) and depression (sucrose preference test-SPT), and voluntary morphine consumption using a two-bottle choice (TBC) paradigm. The results showed that EE experience in morphine-dependent both parents result in an increase in the percentage of time spent into open arms/time spent on both arms using EPM in male offspring, higher levels of sucrose preference in female offspring and lower levels of voluntary morphine consumption in male and female offspring. Thus, EE experience in morphine-dependent both parents reduced anxiety, depressive-like behavior and also the voluntary morphine consumption in their offspring during puberty which may prevent the vulnerability of the next generation to drug abuse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 656, 24 August 2017, Pages 37-42
نویسندگان
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