کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738542 | 1615039 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of N-methyl-d-aspartate receptors during the sensory stimulation-evoked field potential responses in mouse cerebellar cortical molecular layer
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کلمات کلیدی
aCSFNMDARsMFSPFs - PF هاgamma-aminobutyric acid - اسید گاما آمینو بوتیریکmossy fibers - الیاف خرد شدهparallel fibers - الیاف موازیTactile stimulation - تحریک تاکتیکیPurkinje cells - سلول های PurkinjeField potential recording - ضبط میدان میدانparallel fiber - فیبر موازیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیGABA - گاباN-Methyl-d-aspartate receptors - گیرنده های N-methyl-d-aspartate
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The functions of N-methyl-d-aspartate receptors (NMDARs) in cerebellar cortex have been widely studied under in vitro condition, but their roles during the sensory stimulation-evoked responses in the cerebellar cortical molecular layer in living animals are currently unclear. We here investigated the roles of NMDARs during the air-puff stimulation on ipsilateral whisker pad-evoked field potential responses in cerebellar cortical molecular layer in urethane-anesthetized mice by electrophysiological recording and pharmacological methods. Our results showed that cerebellar surface administration of NMDA induced a dose-dependent decrease in amplitude of the facial stimulation-evoked inhibitory responses (P1) in the molecular layer, accompanied with decreases in decay time, half-width and area under curve (AUC) of P1. The IC50 of NMDA induced inhibition in amplitude of P1 was 46.5 μM. In addition, application of NMDA induced significant increases in the decay time, half-width and AUC values of the facial stimulation-evoked excitatory responses (N1) in the molecular layer. Application of an NMDAR blocker, D-APV (250 μM) abolished the facial stimulation-evoked P1 in the molecular layer. These results suggested that NMDARs play a critical role during the sensory information processing in cerebellar cortical molecular layer in vivo in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 660, 1 November 2017, Pages 135-139
Journal: Neuroscience Letters - Volume 660, 1 November 2017, Pages 135-139
نویسندگان
Yin-Hua Xu, Guang-Jian Zhang, Jing-Tong Zhao, Chun-Ping Chu, Yu-Zi Li, De-Lai Qiu,