کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738596 | 1615064 | 2016 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Research articlePhosphodiesterase 10A inhibition attenuates sleep deprivation-induced deficits in long-term fear memory Research articlePhosphodiesterase 10A inhibition attenuates sleep deprivation-induced deficits in long-term fear memory](/preview/png/5738596.png)
- MP-10 ameliorates sleep deprivation-induced long term fear memory deficit.
- REM-SD causes decline of pCREB and BDNF in hippocampus and striatum.
- Recovery of pCREB and BDNF levels by MP-10 benefits long term fear memory.
Sleep, particularly rapid eye movement (REM) sleep, is implicated in the consolidation of emotional memories. In the present study, we investigated the protective effects of a phosphodiesterase 10A (PDE10A) inhibitor MP-10 on deficits in long-term fear memory induced by REM sleep deprivation (REM-SD). REM-SD caused deficits in long-term fear memory, however, MP-10 administration ameliorated the deleterious effects of REM-SD on long term fear memory. Brain-derived neurotropic factor (BDNF) and phosphorylated cAMP response element-binding protein (pCREB) were altered in specific brain regions associated with learning and memory in REM-SD rats. Accordingly, REM-SD caused a significant decrease of pCREB in hippocampus and striatum and a significant decrease of BDNF in the hippocampus, striatum and amygdala, however, MP-10 reversed the effects of REM-SD in a dose-dependent manner. Our findings suggest that REM-SD disrupts the consolidation of long-term fear memory and that administration of MP-10 protects the REM-SD-induced deficits in fear memory, which may be due to the MP-10-induced expression of BDNF in the hippocampus, striatum and amygdala, and phosphorylation of CREB in the hippocampus and striatum.
Journal: Neuroscience Letters - Volume 635, 2 December 2016, Pages 44-50