کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738933 | 1615263 | 2017 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effect of spermine against pentylenetetrazole kindling epilepsy induced comorbidities in mice
ترجمه فارسی عنوان
اثر محافظتی اسپرمین بر پوسیدگی پنتیلن تترازول همراه با کمخونی در موش صحرائی
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کلمات کلیدی
تشنج اختلال شناختی، کینگینگ، پلی آمین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Nitric oxide (NO), an important intracellular signaling molecule is involved in modulation of neuronal transmission. The NO level increases during epileptic activity in animal models of epilepsy. However, its role in epileptic activity remains controversial. Spermine is an endogenous polyamine; possesses anti-oxidant property and has ability to modulate ion channels and NO synthase activity. Therefore, the present study was designed to investigate the role of NO pathway in the neuroprotective effect of spermine, in Pentylenetetrazol (PTZ) induced kindling epilepsy in mice. PTZ (35Â mg/kg; intraperitoneal, i.p.) was administered on every alternate day up to 29Â days and challenge test was performed on 33rd day. From 15th day, spermine (5 and 10Â mg/kg; i.p.), L-NAME (10Â mg/kg; i.p), l-Arginine (50Â mg/kg; i.p) and sodium valproate (400Â mg/kg; i.p.) were administered up to 33rd day. Animals were sacrificed on 34th day for estimation of biochemical and neurotransmitters. Pretreatment with spermine, considerably, reversed the PTZ induced alterations. Further, pretreatment of L-NAME and l-Arginine with 5 and 10Â mg/kg; i.p. spermine, respectively, leads to an increase and decrease in its protective effects. The present study suggests the involvement of NO pathway in the protective effect of spermine against PTZ-induced kindling epilepsy in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 120, July 2017, Pages 8-17
Journal: Neuroscience Research - Volume 120, July 2017, Pages 8-17
نویسندگان
Mandeep Kumar, Puneet Kumar,