کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5739041 | 1615262 | 2017 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Driving and regulating temporal association learning coordinated by entorhinal-hippocampal network
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کلمات کلیدی
Optogenetics - اپتوژنتیکContext - بافت یا متن نوشتهFear conditioning - تهدید ترسEpisodic memory - حافظه اپیزودیکWorking memory - حافظه فعال یا حافظه کاریContextual memory - حافظه متنیTime - زمان prefrontal cortex - قشر prefrontalEntorhinal cortex - قشر انتورینالCircuits - مدارهاTransgenic mice - موش ترانس ژنیکHippocampus - هیپوکامپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Episodic memories shape future behaviour and by aiding adaptive behaviour, are therefore important for survival in nature. Entorhinal cortex (EC)-hippocampal (HPC) networks have a crucial role in the formation of episodic memory, which consists of associations of space, objects, individuals and time. Neural circuits have been identified in the EC-HPC networks that provide spatial, contextual and object information. However, the specific neural circuits that allow animals to associate two temporally segregated events, called temporal association learning, are still nebulous. In this review, I will review recent experimental evidence concerning the role of the EC in temporal association learning, with an emphasis on the neural circuits functioning to drive and regulate the temporal associations between events, and focusing on the trace fear conditioning paradigm in rodents. Then, I will discuss hippocampal activity during the trace periods that may bridge the temporal gap in memory for discontinuous events. Finally, I examine the role of the prefrontal cortex as a central executive system to track and extract predictive relationships between events by the coordination of the EC-HPC network.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 121, August 2017, Pages 1-6
Journal: Neuroscience Research - Volume 121, August 2017, Pages 1-6
نویسندگان
Takashi Kitamura,