کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5739387 1615556 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperTinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Research paperTinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy
چکیده انگلیسی


- Tinnitus participants matched with controls for age, sex, & audiogram up to 14 kHz.
- Tinnitus participants more noise exposed, despite close audiometric matching.
- No ABR or EFR evidence for cochlear synaptopathy in tinnitus participants.
- No association between ABR or EFR measures and lifetime noise exposure.

In rodents, exposure to high-level noise can destroy synapses between inner hair cells and auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such “cochlear synaptopathy” is associated with amplitude reductions in wave I of the auditory brainstem response (ABR) at moderate-to-high sound levels. Similar ABR results have been reported in humans with tinnitus and normal audiometric thresholds, leading to the suggestion that tinnitus in these cases might be a consequence of synaptopathy. However, the ABR is an indirect measure of synaptopathy and it is unclear whether the results in humans reflect the same mechanisms demonstrated in rodents. Measures of noise exposure were not obtained in the human studies, and high frequency audiometric loss may have impacted ABR amplitudes. To clarify the role of cochlear synaptopathy in tinnitus with a normal audiogram, we recorded ABRs, envelope following responses (EFRs), and noise exposure histories in young adults with tinnitus and matched controls. Tinnitus was associated with significantly greater lifetime noise exposure, despite close matching for age, sex, and audiometric thresholds up to 14 kHz. However, tinnitus was not associated with reduced ABR wave I amplitude, nor with significant effects on EFR measures of synaptopathy. These electrophysiological measures were also uncorrelated with lifetime noise exposure, providing no evidence of noise-induced synaptopathy in this cohort, despite a wide range of exposures. In young adults with normal audiograms, tinnitus may be related not to cochlear synaptopathy but to other effects of noise exposure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 344, February 2017, Pages 265-274
نویسندگان
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