کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5739452 1615551 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence of “hidden hearing loss” following noise exposures that produce robust TTS and ABR wave-I amplitude reductions
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Evidence of “hidden hearing loss” following noise exposures that produce robust TTS and ABR wave-I amplitude reductions
چکیده انگلیسی


- Noise burst prepulse inhibition was used to assess hearing-in-noise deficits.
- Temporary threshold shift >30 dB produced hearing-in-noise deficits 2 weeks post-noise.
- Temporary threshold shift >30 dB produced long term ABR wave-I amplitude reductions.
- The degree of ABR wave-I reduction was not correlated with degree of hearing-in-noise deficits.
- The degree of temporary threshold shift was not correlated with degree of hearing-in-noise deficits.

In animals, noise exposures that produce robust temporary threshold shifts (TTS) can produce immediate damage to afferent synapses and long-term degeneration of low spontaneous rate auditory nerve fibers. This synaptopathic damage has been shown to correlate with reduced auditory brainstem response (ABR) wave-I amplitudes at suprathreshold levels. The perceptual consequences of this “synaptopathy” remain unknown but have been suggested to include compromised hearing performance in competing background noise. Here, we used a modified startle inhibition paradigm to evaluate whether noise exposures that produce robust TTS and ABR wave-I reduction but not permanent threshold shift (PTS) reduced hearing-in-noise performance. Animals exposed to 109 dB SPL octave band noise showed TTS >30 dB 24-h post noise and modest but persistent ABR wave-I reduction 2 weeks post noise despite full recovery of ABR thresholds. Hearing-in-noise performance was negatively affected by the noise exposure. However, the effect was observed only at the poorest signal to noise ratio and was frequency specific. Although TTS >30 dB 24-h post noise was a predictor of functional deficits, there was no relationship between the degree of ABR wave-I reduction and degree of functional impairment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 349, June 2017, Pages 155-163
نویسندگان
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