کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5739482 | 1615554 | 2017 | 10 صفحه PDF | دانلود رایگان |
- ABR measurements in response to bone-conduction stimuli are described.
- Bone-conduction responses are little affected by conductive lesions.
- Air- and bone-conduction responses suggest a conductive presbycusis.
- The presented bone-conduction techniques have a limited dynamic range.
While many mouse models of hearing loss have been described, a significant fraction of the genetic defects in these models affect both the inner ear and middle ears. A common method used to separate inner-ear (sensory-neural) from middle-ear (conductive) pathologies in the hearing clinic is the combination of air-conduction and bone-conduction audiometry. In this report, we investigate the use of air- and bone-conducted evoked auditory brainstem responses to perform a similar separation in mice. We describe a technique by which we stimulate the mouse ear both acoustically and via whole-head vibration. We investigate the sensitivity of this technique to conductive hearing loss by introducing middle-ear lesions in normal hearing mice. We also use the technique to investigate the presence of an age-related conductive hearing loss in a common mouse model of presbycusis, the BALB/c mouse.
Journal: Hearing Research - Volume 346, March 2017, Pages 45-54