کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5739529 1615557 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Origins of thalamic and cortical projections to the posterior auditory field in congenitally deaf cats
ترجمه فارسی عنوان
ریشه های پیش بینی های تالام و قشر به زمینه شنوایی خلفی در گربه های ناشنوا مادران
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
چکیده انگلیسی


- The retrograde tracer BDA was injected into PAF of congenitally deaf cats.
- Neurons projecting to PAF were quantified throughout the brain.
- Non-auditory projections to PAF more than doubled compared to hearing cats.
- Ectopic projections were observed from visual and parietal cortical areas.

Crossmodal plasticity takes place following sensory loss, such that areas that normally process the missing modality are reorganized to provide compensatory function in the remaining sensory systems. For example, congenitally deaf cats outperform normal hearing animals on localization of visual stimuli presented in the periphery, and this advantage has been shown to be mediated by the posterior auditory field (PAF). In order to determine the nature of the anatomical differences that underlie this phenomenon, we injected a retrograde tracer into PAF of congenitally deaf animals and quantified the thalamic and cortical projections to this field. The pattern of projections from areas throughout the brain was determined to be qualitatively similar to that previously demonstrated in normal hearing animals, but with twice as many projections arising from non-auditory cortical areas. In addition, small ectopic projections were observed from a number of fields in visual cortex, including areas 19, 20a, 20b, and 21b, and area 7 of parietal cortex. These areas did not show projections to PAF in cats deafened ototoxically near the onset of hearing, and provide a possible mechanism for crossmodal reorganization of PAF. These, along with the possible contributions of other mechanisms, are considered.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 343, January 2017, Pages 118-127
نویسندگان
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