کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5741163 1616991 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Full length articleResveratrol ameliorates oxidative stress and organ dysfunction in Schistosoma mansoni infected mice
ترجمه فارسی عنوان
مقاله کامل مقاله استرساتررول باعث کاهش استرس اکسیداتیو و اختلال عملکرد بدن در موشهای آلوده به شیستوزومای مانسونی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
چکیده انگلیسی


- Schistosoma mansoni causes oxidative stress in most body organs of infected hosts.
- Resveratrol ameliorates oxidative stress in S. mansoni infected mice.
- The antioxidative effect of resveratrol is more pronounced in some organs.

Schistosoma mansoni causes a major chronic debilitating disease in more than 230 million people around the world. The pathognomonic granuloma is a major cause of the oxidative stress encountered as a consequence of infection not only in the liver, but also in other important organs as spleen, lung, brain and kidney. Resveratrol administration at a dose of 20 mg/kg once daily for two weeks to mice infected with Schistosoma mansoni resulted in improvement in serum cholesterol and triglyceride levels. Enzymatic antioxidant profile showed significant modulations in Superoxide dismutase, catalase activities and reduced glutathione levels. Specific biomarkers for homeostasis of brain and lung i.e. Tau and RAGE respectively, showed significant improvement after resveratrol administration.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 174, March 2017, Pages 52-58
نویسندگان
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