The psychoactive pollutant fluoxetine compromises antipredator behaviour in fish

• Mosquitofish (G. holbrooki) exposed to fluoxetine (FLX) at two realistic levels.
• FLX at the lower level increased activity in the presence or absence of a predator.
• FLX at both levels reduced latency to enter predator strike zone.
• FLX caused sex-dependent reduction in ‘freezing’ after a simulated predator strike.
• Exposure to FLX can have detrimental sub-lethal impacts on antipredator behaviour.