کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5749118 | 1619146 | 2017 | 7 صفحه PDF | دانلود رایگان |
- This is the first study to investigate a clear association between indoor air pollution and leukocyte telomere length.
- Chronic exposure to household solid fuel combustion and leukocyte telomere length presented a negative correlation.
- Shortest leukocyte telomere length belonged to population cooking for longest time.
- Education and occupation were remarkably associated with leukocyte telomere length via relating with indoor air pollution.
Indoor air pollution is an important environmental factor that contributes to the burden of various diseases. Long-term exposure to ambient air pollution is associated with telomere shortening. However, the association between chronic indoor air pollution from household fuel combustion and leukocyte telomere length has not been studied. In our study, 137 cancer-free non-smokers were recruited. Their exposure levels to indoor air pollution from 1985 to 2014 were assessed using a face-to-face interview questionnaire, and leukocyte telomere length (LTL) was measured using a monochrome multiplex quantitative PCR method. Accumulative exposure to solid fuel usage for cooking was negatively correlated with LTL. The LTL of residents who were exposed to solid fuel combustion for three decades (LTL = 0.70 ± 0.17) was significantly shorter than that of other populations. In addition, education and occupation were related to both exposure to solid fuel and LTL. Sociodemographic factors may play a mediating role in the correlation between leukocyte telomere length and environmental exposure to indoor air pollution. In conclusion, long-term exposure to indoor air pollution may cause LTL dysfunction.
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Journal: Environmental Pollution - Volume 227, August 2017, Pages 1-7