کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5749185 1619146 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of pyrethroids exposure with onset of puberty in Chinese girls
ترجمه فارسی عنوان
انجمن پریتروئیدها با شروع بلوغ در دختران چینی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


- Urinary pyrethroids metabolites levels were measured in 305 Chinese girls at ages 9-15.
- Pyrethroids levels are negatively correlated with Breast Tanner stage in girls.
- Pyrethroids levels are negatively correlated with Pubic hair Tanner stage in girls.
- Pyrethroids levels are negatively associated with menarche age in girls.

Pyrethroids, a class of ubiquitous insecticides, have been considered as endocrine-disrupting chemicals (EDCs). Female animal studies suggested that early-life pyrethroids exposure might delay puberty onset. However, it remains unclear whether this association applies to human populations. A total of 305 girls at the ages of 9-15 years old were recruited in Hangzhou, China in this study. The concentration of the common metabolite of pyrethroids, 3-phenoxybenzoic acid (3-PBA), was analyzed in urine samples to reflect the exposure level of pyrethroids. The associations of 3-PBA with pubertal stages were evaluated using a multinomial logistic regression model. The geometric mean level of 3-PBA was 1.11 μg/L (1.42 μg/g for creatinine-adjusted concentration). There was a significant 45% reduction in odds of being in breast stage 3 (B3) per one-unit increase in the log-transformed 3-PBA levels [OR = 0.55 (95%CI: 0.31-0.98), p = 0.042]. A similar negative association was found between urinary 3-PBA levels with later onset by pubic hair stage 2 (P2) [OR = 0.56 (95%CI: 0.36-0.90), p = 0.015]. Similar negative association was also observed between urinary 3-PBA levels and pubertal onset indicated by menarche [OR = 0.51 (95%CI: 0.28-0.93), p = 0.029]. For the first time to our knowledge, this work reveals that pyrethroids exposure may increase the risk of delayed pubertal onset in girls.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 227, August 2017, Pages 606-612
نویسندگان
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