کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5761980 | 1624814 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential anti-proliferative effect on K562 leukemia cells of Lippia alba (Verbenaceae) essential oils produced under diverse growing, collection and extraction conditions
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم زراعت و اصلاح نباتات
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چکیده انگلیسی
Lippia alba (Verbenaceae Family) is an aromatic shrub native to Latin America, with recognized medicinal properties and a well-known high phenotypical plasticity in response to environmental factors. In order to identify the parameters that potentiate its in vitro anti-proliferative effect on human leukemia cells (K562), a matrix was designed for the production of 76 essential oils (EOs) with variations in plant growing season, harvested part from the plant, and preservation and distillation material conditions. The results show that EOs obtained from the same L. alba chemotype (Citral or Carvone), but acquired under different environmental or extraction conditions, presented significant differences in their primary components, oil yield, and cytotoxic activity on K562 cells. Citral EOs produced under diverse conditions displayed a cytotoxic effect on tumour cells ranging from 54 to 95% (IS 1.8-8.6) and IC50 from 13 to 38.8 μg/mL. The differences in antiproliferative activity were significantly correlated with variations in the β-caryophyllene oxide concentration. These results show the value of using standardized production conditions for the commercial utilization of L. alba EOs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Industrial Crops and Products - Volume 96, February 2017, Pages 140-148
Journal: Industrial Crops and Products - Volume 96, February 2017, Pages 140-148
نویسندگان
Liliana Torcoroma GarcÃa, Andrés Felipe Leal, Ãrika Marcela Moreno, Elena E. Stashenko, H. José Arteaga,