Proteome pattern in oysters as a diagnostic tool for metal pollution

► Principal components analysis revealed that the oysters had distinct contamination profiles. ► Proteomic analysis identified a proteome pattern composed of 13 commonly altered proteins in the contaminated oysters. ► The proteome pattern could classify the oysters with different comtanination levels. ► The integrated proteome change were linearly related to the integrated contamination of the metal mixtures. ► Proteome pattern is a promising diagnostic tool for metal pollution assessment.