Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans

► Chronic exposure to Al2O3-NP caused adverse effects on locomotion behaviors. ► Chronic Al2O3-NP exposure induced ROS production and ROS defense mechanism disruption. ► sod-2 and sod-3 mutants were susceptible to Al2O3-NP-induced neurotoxicity inhibition.