کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5788769 1414269 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewBrown adipose tissue and its therapeutic application
ترجمه فارسی عنوان
بررسی چربی بافت چربی و کاربرد درمانی آن
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

In addition to white adipose tissue (WAT) that stores energy, human and small mammals also have brown adipose tissue (BAT) that dissipates chemical energy for thermogenesis. BAT contains multilocular lipid droplets and much higher numbers of mitochondria than WAT. The mitochondria in BAT uncouple large amounts of fuel oxidation from ATP for heat generation. Accumulating evidences have demonstrated that increased activity and/or amount of BAT can reverse obesity and improve insulin resistance, which highlights that BAT plays an important role in energy metabolism. In this review, we summarized recent findings that shows advantageous effects of BAT activation in metabolic diseases. In addition, we presented the function and role of brown and beige fat cells and regulatory factors for them. Finally, we discussed the potential application of brown adipocytes-based therapy and pharmacological intervention to increase BAT activity for the treatment of obesity and related diseases including insulin resistance, cardiovascular diseases and type 2 diabetes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science Bulletin - Volume 61, Issue 19, October 2016, Pages 1498-1503
نویسندگان
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