کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5788946 | 1414282 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel o-nitrobenzyl-based photocleavable antitumor prodrug with the capability of releasing 5-fluorourail
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
An o-nitrobenzyl-based photocleavable antitumor prodrug with a terminal carboxyl group was designed and synthesized. The photolysis properties of the prodrug were investigated by means of 1H NMR, HPLC, UV, and MTT methods. The results showed that the toxicity of the anticancer drug was effectively shielded before release. However, the prodrug effectively regained the antitumor capability against cancer cells by release of 5-fluorouracil when it was exposed to ultraviolet irradiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science Bulletin - Volume 61, Issue 6, March 2016, Pages 459-467
Journal: Science Bulletin - Volume 61, Issue 6, March 2016, Pages 459-467
نویسندگان
Shuli Mo, Ying Wen, Fengfeng Xue, Haichuang Lan, Yueyuan Mao, Guanglei Lv, Tao Yi,