کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5789558 | 1553758 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intracerebral Malignant Plasmacytoma in a Mule Deer (Odocoileus hemionus)
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
A wild, mature, gravid female mule deer (Odocoileus hemionus) was presented with marked neurological signs, including abnormal behaviour, circling and incoordination. The animal was humanely destroyed and submitted for diagnostic investigation. Grossly, a well-demarcated, 3Â ÃÂ 3Â ÃÂ 3Â cm intracranial mass replaced the left olfactory bulb and frontal lobe. Histologically, there was a highly cellular, infiltrative and unencapsulated neoplastic mass of round cells with eccentrically located nuclei. Neoplastic cells were immunohistochemically labelled for lambda immunoglobulin light chain. Clusters of CD20- and CD79a-positive cells were scattered throughout the tumour and CD3- and Iba1-positive cells diffusely infiltrated the neoplasm. Ultrastructurally, the cytoplasm of the neoplastic cells had prominent rough endoplasmic reticulum with a variable degree of dilation. Histopathological, immunohistochemical and electron microscopical results were diagnostic for a solitary extramedullary plasmacytoma. Intracranial neoplasms are rarely diagnosed in wildlife species, but they should be included in the differential diagnosis for potential causes of central nervous system disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 154, Issues 2â3, FebruaryâApril 2016, Pages 268-271
Journal: Journal of Comparative Pathology - Volume 154, Issues 2â3, FebruaryâApril 2016, Pages 268-271
نویسندگان
C.S. Clancy, A. Roug, A.G. Armien, A.J. Van Wettere,