کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5794502 | 1554305 | 2016 | 5 صفحه PDF | دانلود رایگان |

- Sarcoid skin is less permissive for acyclovir permeation compared to normal skin.
- Even in sarcoid skin, considerable acyclovir concentrations are found in the dermis.
- Research should now focus on the susceptibility of BPV DNA polymerase for acyclovir.
Topical acyclovir application is an owner-friendly treatment for occult equine sarcoids, without the caustic side-effects other topical treatments have. Variable clinical success rates have been described, but it is not known to what rate and extent acyclovir penetrates in and through equine skin from a topical formulation.In the current study, an in vitro Franz diffusion model was used to determine the permeation parameters for a generic 5% acyclovir cetomacrogol cream for both healthy and sarcoid equine skin. The distribution of acyclovir between different layers of both skin types was also evaluated.While acyclovir penetrated through both skin types, significantly less acyclovir permeated to the deep dermis of sarcoid skin (197.62Â ng/mm3) compared to normal skin (459.41Â ng/mm3). Within sarcoid skin samples, significantly higher acyclovir concentrations were found in the epidermis (983.59Â ng/mm3) compared to the superficial dermis (450.02Â ng/mm3) and the deep dermis. At each sample point, significantly more acyclovir permeated to the receptor fluid through normal skin compared to sarcoid skin, which is reflected in the significantly higher permeation parameters of normal skin.Normal skin was found to be more permissive for acyclovir, but even in sarcoid skin, enough acyclovir reached the deep dermis to treat a Herpes simplex virus infection. In the case of equine sarcoids, the treatment is aimed at the Bovine papillomavirus and no information is available on the susceptibility of the DNA polymerase of this virus for acyclovir. Therefore, further research is needed to determine the efficacy of acyclovir to treat equine sarcoids.
Journal: Research in Veterinary Science - Volume 106, June 2016, Pages 107-111