کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5794697 1554311 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
چکیده انگلیسی


- Garcinia hombroniana leaves aqueous extract exerts anti-Trypanosoma evansi effect.
- This effect is possibly via the inhibition of trypanosomal kinetoplast division.
- The plant could serve as a possible source of new antitrypanosomal compounds.

The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague-Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), compared to the untreated control group. The possible mode of antitrypanosomal effect of the plant extract was also investigated on cultured T. evansi in HMI-9 medium with the addition of 25 µg/ml G. hombroniana aqueous extract. It was observed that the addition of G. hombroniana extract resulted in the inhibition of trypanosomal kinetoplast division, with no significant inhibitory effect on nuclear division. It is concluded from the current study that the aqueous extract of G. hombroniana has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 100, June 2015, Pages 226-231
نویسندگان
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