کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5794697 | 1554311 | 2015 | 6 صفحه PDF | دانلود رایگان |

- Garcinia hombroniana leaves aqueous extract exerts anti-Trypanosoma evansi effect.
- This effect is possibly via the inhibition of trypanosomal kinetoplast division.
- The plant could serve as a possible source of new antitrypanosomal compounds.
The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague-Dawley rats. Treatment of infected rats with G.âhombroniana extract resulted in a significantly extended post-infection longevity (pâ<â0.05), compared to the untreated control group. The possible mode of antitrypanosomal effect of the plant extract was also investigated on cultured T.âevansi in HMI-9 medium with the addition of 25âµg/ml G.âhombroniana aqueous extract. It was observed that the addition of G.âhombroniana extract resulted in the inhibition of trypanosomal kinetoplast division, with no significant inhibitory effect on nuclear division. It is concluded from the current study that the aqueous extract of G.âhombroniana has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds.
Journal: Research in Veterinary Science - Volume 100, June 2015, Pages 226-231