کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5795408 1554350 2016 5 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Keys to solving health problems in small ruminants: Anthelmintic resistance as a threat to sustainable nematode control
ترجمه فارسی عنوان
کلید حل مسائل بهداشتی در یادگیری های کوچک: مقاومت آنتیگلمینتیک به عنوان یک تهدید برای کنترل پایدار نماتدها
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


- Nematode control must shift from attempts to eliminate parasites, towards management and treatments to maintain health in the face of challenge.
- Publication of a genome and transcriptome for Haemonchus contortus, affords opportunities for post genomic research.
- Need to identify molecular markers to evaluate resistance management and candidates for novel control methods.
- Unprecedented opportunities now exists for collaboration between veterinary practitioners and research scientists.
- Post genomic research must identify solutions to sustainable small ruminant production.

The epidemiology of nematode parasites has changed as they have adapted to climatic and management changes and as a consequence of the inappropriate use of anthelmintic drugs. This adaptability is conferred by large, polymorphic genomes and r-reproductive strategies. A significant net effect of these factors has been the emergence of anthelmintic resistance. Consequently, blueprint control programmes have failed and suboptimal sheep productivity due to nematode parasites has become commonplace. The focus of veterinary nematode control in intensively managed sheep flocks and goat herds must shift from attempts to eliminate parasite populations, towards the adoption of management and anthelmintic drug treatment strategies aimed at maintaining adequate standards of health in the face of a low level of challenge. Conventional parasitological methods are useful for the diagnosis of disease and for monitoring of nematode management over time, but they lack the sensitivity needed to mitigate effects of climate and management on population genetics of the parasites. The publication of a draft genome and transcriptome for the model nematode parasite, Haemonchus contortus, affords opportunities for post genomic research to identify sensitive molecular markers to evaluate resistance management strategies and potential candidates for novel control methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Small Ruminant Research - Volume 142, September 2016, Pages 11-15
نویسندگان
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