کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5806537 1555915 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational tools for epitope vaccine design and evaluation
ترجمه فارسی عنوان
ابزار محاسباتی برای طراحی و ارزیابی واکسن های اپیتوپنی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
Rational approaches will be required to develop universal vaccines for viral pathogens such as human immunodeficiency virus, hepatitis C virus, and influenza, for which empirical approaches have failed. The main objective of a rational vaccine strategy is to design novel immunogens that are capable of inducing long-term protective immunity. In practice, this requires structure-based engineering of the target neutralizing epitopes and a quantitative readout of vaccine-induced immune responses. Therefore, computational tools that can facilitate these two areas have played increasingly important roles in rational vaccine design in recent years. Here we review the computational techniques developed for protein structure prediction and antibody repertoire analysis, and demonstrate how they can be applied to the design and evaluation of epitope vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Virology - Volume 11, April 2015, Pages 103-112
نویسندگان
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