کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5806805 | 1555921 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective immunity against HEV
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Rural community of Dongtai City in eastern China is endemic for hepatitis E virus (HEV), with the zoonotic genotype 4 virus predominating. The virus appears to be widely distributed in environment at generally low levels, such that infection is common, but >97% of which are asymptomatic and provoke a modest antibody response. Naturally acquired immunity affords 75% protection against infection, prevents disease caused by primary infection and alleviates severity of the disease caused by the residual infection that had evaded host immune surveillance. The protection, however, is extended to a minority, while leaving the majority of population essentially without the benefits of immune protection. Vaccination affords similar level of protection as does natural immunity, but expands the protective coverage to the entire population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Virology - Volume 5, April 2014, Pages 1-6
Journal: Current Opinion in Virology - Volume 5, April 2014, Pages 1-6
نویسندگان
Shou-Jie Huang, Xiao-Hui Liu, Jun Zhang, Mun-Hon Ng,