Pathogenesis of rhinovirus infection

► Rhinovirus is a ubiquitous virus and the usual cause of the common cold, yet little is known regarding its pathogenic mechanisms. ► The upper and lower airways are the primary targets of RV, but, surprisingly, this virus causes little cytopathology. ► Many patients will have positive tests to RV, yet remain subclinical. ► The host epithelial barriers and both innate and adaptive immune responses influence the reaction of the host. ► The various immune responses lead to the distinct outcomes from subclinical to severe and even life-threatening infections.