کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5809931 1556185 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Imitation of phase I oxidative metabolism of anabolic steroids by titanium dioxide photocatalysis
ترجمه فارسی عنوان
تقلید متابولیسم اکسیداتیو فاز اول استروئید آنابولیک توسط فوتوکاتالیز دی اکسید تیتانیوم
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

The aim of this study was to investigate the feasibility of titanium dioxide (TiO2) photocatalysis for oxidation of anabolic steroids and for imitation of their phase I metabolism. The photocatalytic reaction products of five anabolic steroids were compared to their phase I in vitro metabolites produced by human liver microsomes (HLM). The same main reaction types - hydroxylation, dehydrogenation and combination of these two - were observed both in TiO2 photocatalysis and in microsomal incubations. Several isomers of each product type were formed in both systems. Based on the same mass, retention time and similarity of the product ion spectra, many of the products observed in HLM reactions were also formed in TiO2 photocatalytic reactions. However, products characteristic to only either one of the systems were also formed. In conclusion, TiO2 photocatalysis is a rapid, simple and inexpensive method for imitation of phase I metabolism of anabolic steroids and production of metabolite standards.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 65, 18 December 2014, Pages 45-55
نویسندگان
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