کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5813225 | 1556608 | 2016 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peripheral ammonia and blood brain barrier structure and function after methamphetamine
ترجمه فارسی عنوان
بعد از متامفتامین، ساختار و عملکرد مانع آمونیاک محیطی و مغزی خون
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کلمات کلیدی
متامفتامین، آمونیاک مانع خون مغزی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
An effect of the widely abuse psychostimulant, methamphetamine (Meth), is blood-brain-barrier (BBB) disruption; however, the mechanism by which Meth causes BBB disruption remains unclear. Recently it has been shown that Meth produces liver damage and consequent increases in plasma ammonia. Ammonia can mediate oxidative stress and inflammation, both of which are known to cause BBB disruption. Therefore, the current studies examined the role of peripheral ammonia in Meth-induced disruption of BBB structure and function. A neurotoxic Meth regimen (10Â mg/kg, ip, q 2Â h, Ã4) administered to rats increased plasma ammonia and active MMP-9 in the cortex 2Â h after the last Meth injection, compared to saline treated rats. At 24Â h after Meth treatment, decreased immunoreactivity of BBB structural proteins, occludin and claudin-5, and increased extravasation of 10,000Â Da FITC-dextran were observed, as compared to saline controls. Pretreatment with lactulose (5.3Â g/kg, po, q 12Â h), a drug that remains in the lumen of the intestine and promotes ammonia excretion, prevented the Meth-induced increases in plasma ammonia. These results were paralleled by the prevention of decreases in BBB structural proteins, increases in extravasation of 10,000Â Da FITC-dextran and increases in active MMP-9. The results indicate that Meth-induced increases in ammonia produce BBB disruption and suggest that MMP-9 activation mediates the BBB disruption. These findings identify a novel mechanism of Meth-induced BBB disruption that is mediated by plasma ammonia and are the first to identify a peripheral contribution to Meth-induced BBB disruption.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 107, August 2016, Pages 18-26
Journal: Neuropharmacology - Volume 107, August 2016, Pages 18-26
نویسندگان
Nicole A. Northrop, Laura E. Halpin, Bryan K. Yamamoto,