کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5813393 | 1556610 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The CRF1 and the CRF2 receptor mediate recognition memory deficits and vulnerability induced by opiate withdrawal
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The CRF1 and the CRF2 receptor mediate recognition memory deficits and vulnerability induced by opiate withdrawal The CRF1 and the CRF2 receptor mediate recognition memory deficits and vulnerability induced by opiate withdrawal](/preview/png/5813393.png)
چکیده انگلیسی
Opiate use disorders are associated with impaired cognitive function and altered stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates stress responses via CRF1 and CRF2 receptors and may be implicated in substance use disorders. However, the specific role for each of the two known CRF receptor subtypes in cognitive impairment induced by opiate administration and withdrawal remains to be elucidated. In the present study, CRF1â/â, CRF2â/â and their respective wild-type mice are injected with escalating doses of morphine and cognitive function assessed by the novel object recognition (NOR) memory task throughout relatively long periods of opiate withdrawal. Early (2 days) phases of opiate withdrawal impair NOR memory in wild-type, CRF1â/â and CRF2â/â mice. However, the duration of opiate withdrawal-induced NOR memory deficits is prolonged in CRF1â/â but shortened in CRF2â/â mice, as compared to their respective wild-type mice, indicating opposite roles for the two CRF receptor subtypes. Nevertheless, following apparent recovery, exposure to an environmental stressor induces the reemergence of NOR memory deficits in long-term opiate-withdrawn wild-type but not CRF1â/â or CRF2â/â mice, indicating an essential role for both CRF receptor subtypes in stress vulnerability. These findings bring initial evidence of a complex physiopathological role for the CRF system in cognitive deficits and the long-lasting vulnerability induced by opiate drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 105, June 2016, Pages 500-507
Journal: Neuropharmacology - Volume 105, June 2016, Pages 500-507
نویسندگان
Nadège Morisot, Angelo Contarino,