کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5813471 | 1556607 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Unraveling a new circuitry for sleep regulation in Parkinson's disease
ترجمه فارسی عنوان
باز کردن یک مدار جدید برای تنظیم خواب در بیماری پارکینسون
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
REMSDGPiPPTSTNGPEREMDHPGDOPACNREMSubstantia nigra pars reticulata3,4-dihydroxyphenylacetic acid - 3،4-دی هیدروکسی فنیل اسیدهای اسیدDMSO - DMSOexternal globus pallidus - globus pallidus خارجیinternal globus pallidus - globus pallidus داخلیSNpc - SNPCSNpr - SNPRStriatum - استریاتومParkinson's disease - بیماری پارکینسونSleep regulation - تنظیم خوابsubstantia nigra - توده سیاهsubstantia nigra pars compacta - توده سیاه پارس متراکمtyrosine hydroxylase - تیروزین هیدروکسیلازNon-rapid eye movement sleep - حرکت سریع چشم بدون خوابrapid eye movement sleep - حرکت چشم سریع خوابDopamine - دوپامینDimethylsulfoxide - دیمتیل سولفواکسیدRapid eye movement sleep deprivation - محرومیت سریع از حرکت چشمPedunculopontine nucleus - هسته Pedunculopontinepedunculopontine tegmental nucleus - هسته تمثالی pedunculopontineSubthalamic nucleus - هسته ی زیرهالامیکhomovanillic acid - هومووانیلیک اسیدChAT - چتHVA - چهcholine acetyltransferase - کولین استیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Sleep disturbances are among the most disabling non-motor symptoms in Parkinson's disease. The pedunculopontine tegmental nucleus and basal ganglia are likely involved in these dysfunctions, as they are affected by neurodegeneration in Parkinson's disease and have a role in sleep regulation. To investigate this, we promoted a lesion in the pedunculopontine tegmental nucleus or substantia nigra pars compacta of male rats, followed by 24Â h of REM sleep deprivation. Then, we administrated a dopaminergic D2 receptor agonist, antagonist or vehicle directly in the striatum. After a period of 24Â h of sleep-wake recording, we observed that the ibotenic acid infusion in the pedunculopontine tegmental nucleus blocked the so-called sleep rebound effect mediated by REM sleep deprivation, which was reversed by striatal D2 receptors activation. Rotenone infusion in the substantia nigra pars compacta also blocked the sleep rebound, however, striatal D2 receptors activation did not reverse it. In addition, rotenone administration decreased the time spent in NREM sleep, which was corroborated by positive correlations between dopamine levels in both substantia nigra pars compacta and striatum and the time spent in NREM sleep. These findings suggest a new circuitry for sleep regulation in Parkinson's disease, involving the triad composed by pedunculopontine nucleus, substantia nigra pars compacta and striatum, evidencing a potential therapeutic target for the sleep disturbances associated to this pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 108, September 2016, Pages 161-171
Journal: Neuropharmacology - Volume 108, September 2016, Pages 161-171
نویسندگان
Adriano D.S. Targa, Lais S. Rodrigues, Ana Carolina D. Noseda, Mariana F. Aurich, Monica L. Andersen, Sergio Tufik, Cláudio da Cunha, Marcelo M.S. Lima,