کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5813546 | 1556613 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Incubation of cocaine-craving relates to glutamate over-flow within ventromedial prefrontal cortex
ترجمه فارسی عنوان
انکوباسیون کوکائین-اشتعال مربوط به جریان بیش از حد گلوتامات در ناحیه قشر پیش فرنتن ونتومدیال است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Craving elicited by drug-associated cues intensifies across protracted drug abstinence - a phenomenon termed “incubation of craving” - and drug-craving in human addicts correlates with frontal cortical hyperactivity. Herein, we employed a rat model of cue-elicited cocaine-craving to test the hypothesis that the time-dependent incubation of cue-elicited cocaine-craving is associated with adaptations in dopamine and glutamate neurotransmission within the ventromedial prefrontal cortex (vmPFC). Rats were trained to self-administer intravenous cocaine (6 h/day Ã 10 days) and underwent in vivo microdialysis procedures during 2 h-tests for cue-elicited cocaine-craving at either 3 or 30 days withdrawal. Controls rats were trained to either self-administer sucrose pellets or received no primary reinforcer. Cocaine-seeking rats exhibited a withdrawal-dependent increase and decrease, respectively, in cue-elicited glutamate and dopamine release. These patterns of neurochemical change were not observed in either control condition. Thus, cue-hypersensitivity of vmPFC glutamate terminals is a biochemical correlate of incubated cocaine-craving that may stem from dopamine dysregulation in this region.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 102, March 2016, Pages 103-110
Journal: Neuropharmacology - Volume 102, March 2016, Pages 103-110
نویسندگان
Christina B. Shin, Michela M. Serchia, John R. Shahin, Micaela A. Ruppert-Majer, Tod E. Kippin, Karen K. Szumlinski,