Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: The role of inhibition of Drp1 in ischemic brain damage

Ischemia injury induced bulk autophagy as well as selective mitophagy. Drp-1 mediated mitochondrial fission is the premise of ischemia induced mitophagy that could timely remove of the injured mitochondria and decrease the mitochondria-mediated apoptosis. Mdivi-1 selectively inhibited the translocation of Drp-1 to mitochondria and thus blocked the process of mitophagy. The accumulation of mitochondria exaggerated the ischemia injury by increasing the release of cyt-c, AIF, ROS and so on.