Differential contribution of mesoaccumbens and mesohabenular dopamine to intracranial self-stimulation

► Amphetamine was infused into the nucleus accumbens shell, core and lateral habenula of self-stimulating rats. ► We measured changes in rewarding effectiveness and operant responding. ► Rewarding effectiveness was preferentially sensitive to shell infusions. ► Operant responding was preferentially sensitive to core infusions. ► Lateral habenula infusions did not alter either variable.