Motivational properties of D2 and D3 dopamine receptors agonists and cocaine, but not with D1 dopamine receptors agonist and l-dopa, in bilateral 6-OHDA-lesioned rat

► Hypothesis: DRT induces a potential rewarding effect in an animal model of PD. ► Method: The motivational effects of DRT and cocaine assessed using the CPP paradigm. ► Conclusion: Predominant roles D3R subtypes in rewarding properties of DRT.