Effects of lurasidone in behavioral models of depression. Role of the 5-HT7 receptor subtype

► Lurasidone has high affinity for 5-HT7 receptors, a proposed target for depression. ► Lurasidone acted antidepressant-like in the tail suspension and forced swim tests. ► The effect of lurasidone was absent in mice lacking the 5-HT7 receptor. ► In the repeated open-space swim test lurasidone had an effect similar to citalopram. ► Lurasidone acts as a 5-HT7 receptor antagonist and can be used as an antidepressant.