Central administration of angiotensin IV rapidly enhances novel object recognition among mice

► Cognitive-enhancing effects of i.c.v. angiotensin IV (Ang IV) characterized in mice. ► Ang IV dose-dependently (0.1-10 nmol) enhances novel object recognition (NOR). ► Ang IV enhancement of NOR performance occurs rapidly, but of brief duration. ► Ang IV receptor antagonist blocks Ang IV-mediated enhancement of NOR. ► Alanine scan of Ang IV suggests three residues contributing to procognitive core.