کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5814784 1556643 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Time-dependent effects of corticosterone on reward-based decision-making in a rodent model of the Iowa Gambling Task
ترجمه فارسی عنوان
اثرات وابسته به زمان وابسته به کورتیکواسترون بر تصمیم گیری بر اساس پاداش در یک مدل جوندگان از وظیفه قمار آیووا
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی

Corticosteroid hormones, released after stress, are known to change neuronal activity in two time-domains: within minutes via non-genomic pathways and with a delay of >1 h through pathways involving transcriptional regulation. Recent evidence in rodents and humans indicates that these two modes of corticosteroid action differently affect cognitive tasks. Here, we investigated whether reward-based decision-making, in a rat model of the Iowa Gambling Task (rIGT), is also differently altered by rapid versus delayed actions of corticosterone. We targeted the rapid and delayed time domain by injecting corticosterone (CORT, 1 mg/kg, s.c.) at 30 min (rapid) or 180 min (delayed) respectively prior to behavioural testing, during the final 3 days of the behavioural paradigm. In saline treated rats, the number of visits to the disadvantageous arm decreased over trial blocks, whilst this was attenuated when CORT was administered 30 min before testing. This attenuation was associated with a significantly increased c-Fos expression in the lateral orbitofrontal cortex and insular cortex, and a trend for an increase in the infralimbic cortex. The rapid corticosteroid effect contrasted with treatment 180 min before testing, where the number of visits to the disadvantageous arm as well as c-Fos labelling was not affected. These findings indicate that rapid corticosteroid actions impair reward-based decision-making.

► We tested the effects of corticosterone in a rodent model of the Iowa Gambling Task. ► Corticosterone was injected 30 min (rapid) or 180 min (delayed) prior to testing. ► Rapid corticosteroid action impaired decision-making; delayed did not. ► This rapid action was associated with changes in prefrontal c-Fos expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 70, July 2013, Pages 306-315
نویسندگان
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