Metabotropic glutamate 7 (mGlu7) receptor: A target for medication development for the treatment of cocaine dependence

► mGlu7 receptors inhibited the reinforcing and motivational effects of cocaine. ► mGlu7 receptors inhibited the reward-enhancing effects induced by cocaine. ► mGlu7 receptors inhibited cocaine-induced reinstatement of drug-seeking behavior. ► mGlu7 receptors are important target for the treatment of drug dependence.