Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu4 receptor

► Brain penetrating new positive allosteric modulator mGlu4 Lu AF21934 was used. ► The compound exerts anxiolytic but not antidepressant efficacy. ► Anxiolytic action of the drug depends on the GABAergic but not serotonergic system.