Impact of early-life stress, on group III mGlu receptor levels in the rat hippocampus: Effects of ketamine, electroconvulsive shock therapy and fluoxetine treatment

► Early-life stress-induced using maternal separation significantly reduced hippocampal mGlu4 receptor expression. ► Chronic fluoxetine reversed this early-life stress-induced change to mGlu4 expression. ► Chronic fluoxetine and ECT treatment significantly increased hippocampal mGlu7 receptor expression in NS animals.